PSY-802 Literature Review Resources
Number Article Information Added to RefWorks? (Y or N)
1. Bibliographic Information
Bibbo, G., Kirkwood, I., Sigalas, V., &Benger, T. (2019). Radioiodine (131I) therapy in a child with autism spectrum disorder: A complex and demanding task. World Journal of Nuclear Medicine, 18(3), 293295. https://doi-org.lopes.idm.oclc.org/10.4103/wjnm.WJNM_40_18
Study was completed on an 11-year-old male with the diagnosis of autism. The child was initially referred for radioiodine therapy also known as RAI. The child was studied to determine if a 48-72 hour isolation would result in him swallowing a RAI capsule. Barriers for the patient were his behavioral issues related to his autism, mild I/DD (intellectual developmental disability), and his parental environment. His mother was convinced he would not swallow and the capsule or be agreeable with the isolation time period. As a result, a multidisciplinary team was developed in order to aid in his successful treatment. Several options were considered such as regular, frequent contact between the child, his parents, and members of the team for counseling and behavioral modification, familiarization of the child with the staff, procedures, trial visits, and admission. The team determined behavioral therapy to be the only possible option. As a result, the patient was successful in his treatment.
2. Bibliographic Information
Dae-Wook Kang, James B. Adams, Devon M. Coleman, Elena L. Pollard, Juan Maldonado, Sharon McDonough-Means,RosaKrajmalnik-Brown. (2019). Long-term benefit of Microbiota Transfer Therapy on autism symptoms and gut microbiota. Scientific Reports, (1), 1. https://doi-org.lopes.idm.oclc.org/10.1038/s41598-019-42183-0
Historically, there has been several studies completed that report abnormal gut microbiota in people with autism. In these studies it has been suggested that there is a link between autism and gut microbiome. As a result, study was completed utilizing open-label trials of microbiota transfer therapy otherwise known as MTT. This study combined antibiotics, bowel cleansing, stomach acid suppressants and fecal microbiota transplant from a healthy microbiota donor. In the study 18 participants were involved. Follow-up 2 years after their treatments showed positive results. Gastrointestinal symptoms as well as microbiota were maintained over this time frame. In addition, autism related symptoms also showed improvement. During these observations is was determined that MTT not only was very effective but also and safety as a future therapy to treat autism who also have gastrointestinal issues.
3. Bibliographic Information
Gilles Maussion, Cecilia Rocha, Genevive Bernard, Lenore K. Beitel, & Thomas M. Durcan. (2019). , Another in vitro Model, or the Missing Link Toward Novel Therapies for Autism Spectrum Disorders? Frontiers in Pediatrics. https://doi-org.lopes.idm.oclc.org/10.3389/fped.2019.00225
Autism is known historically as a multigenic, multi-factorial, and neuro developmental disorder that is typically diagnosed in early childhood. Autism leads to deficits in social skills, verbal and non-verbal communication. In addition, autism is characterized by restricted and repetitive behaviors and interests. In order to understand the genetic, descriptive and mechanistic aspects of autism, several studies have been conducted. Mouse models and postmortem brain tissue have also been studied in order to better understand and treat autism. Today, the technology to now generate stem cells from patient samples has brought breakthrough for autism through 2D and 3D neuronal models. The goal is to build new therapeutic strategies for treatment. Through these studies of mouse models and human samples advancement in the knowledge and pathophysiology of autism can be discovered. Thus, considering the complexities of these disorders, patient-derived models have immense potential to clarify molecular deregulation that contributed to the different autistic phenotype. Through these direct investigations with the human in vitro models, they offer the potential for opening new therapeutic avenues.
4. Bibliographic Information
Ruu-Fen Tzang, Chuan-Hsin Chang, Yue-Cune Chang, & Hsien-Yuan Lane. (2019). Autism Associated With Anti-NMDAR Encephalitis: Glutamate-Related Therapy. Frontiers in Psychiatry. https://doi-org.lopes.idm.oclc.org/10.3389/fpsyt.2019.00440
This study was conducted to determine if autism is in fact associated with autoimmune dysfunction. There are several auto antibodies that can cause psychiatric symptoms such as hallucinations, psychosis, behavioral changes and so on. The auto antibody binds to certain brain receptors which cause the neuro transmission in the brain to manifest these symptoms. During the study there was detection of these auto antibodies affecting several imbalances in the blood. In addition several infections were noted in the patients history. The childs medical history and lab reports show significant signs of auto immune autism. It is determined in the study that early detection of these autoimmune encephalitis can potentially increase the effects of the treatments. With the aid of these treatments the symptoms that are resulted from the antibodies could be minimized or eliminated completely. This study has concluded that immune therapies could potentially prevent long-term effects for auto immune autism. Findings in the study show glutamate therapy is most effective in bringing the neuro transmitters back to normal range, in addition to being an additional intervention to medication for treatment.
5. Bibliographic Information
Stephanie Saaybi, NatallyAlArab, Salem Hannoun, MarithereseSaade, Rayyan Tutunji, Carine Zeeni, Rose-Mary Boustany. (2019). Pre- and Post-therapy Assessment of Clinical Outcomes and White Matter Integrity in Autism Spectrum Disorder: Pilot Study. Frontiers in Neurology. https://doi-org.lopes.idm.oclc.org/10.3389/fneur.2019.00877
This study was conducted to determine if diffusion tensor imaging (DTI) can identify white matter tract abnormalities in autism. MRI was conducted to gather baseline results in order to compare results after the study to determine improvement or no changes. The study was completed on toddlers and preschoolers who have been diagnosed with autism. Image findings with clinical improvement were compared after early interventions as well as, applied behavior analysis (ABA) therapy by verbal behavior milestones assessments. Placement program methods were also completed utilizing DTI scans. These studies were completed on a total of 17 toddlers with autism diagnoses. DTI findings showed that autism patients white matter abnormalities showed benefits of the early interventions and ABA therapy on clinical and imaging outcomes.
6. Bibliographic Information
Benger, M., Kinali, M., & Mazarakis, N. D. (2018). Autism spectrum disorder: Prospects for treatment using gene therapy. Molecular Autism, (1), 1. doi:10.1186/s13229-018-0222-8
In this study gene replacement therapy is performed in patients with Autism Spectrum disorder (ASD) This study was completed over a period of five years. genetherapy offers a promising alternative to conventional small molecule therapies. Preclinical studies over the last 5 years usinganimal models displaying autism-like traits have demonstrated that directly altering gene expression usingrAAV-delivered transgenes can reverse the behavioral phenotype, either via gene replacement or RNA knockdown. Such and set up a platform for clinical translation in various monogenic ASDs, with RS being a frontrunner in this regard. However, there is still much more research and barriers to gene therapy that need to be overcome first before this therapy can be offered to the public. There are many factors that need to be considered first such as hereditary factors which was explored some in this case study.
7. Bibliographic Information
Caputo, G., Ippolito, G., Mazzotta, M., Sentenza, L., Muzio, M. R., Salzano, S., &Conson, M. (2018). Effectiveness of a multisystem aquatic therapy for children with autism spectrum disorders. Journal of Autism & Developmental Disorders, 48(6), 1945-1956. doi:10.1007/s10803-017-3456-y Y
This study tested to see is aqua therapy would be a form of successful treatment for children with Autism Spectrum Disorder. Aqua therapy has been successful in other illnesses and disabilities to improve overall motor skills and improving injuries. It has been believed that aqua therapy would also be successful in improving the motor skills in children with Autism Spectrum disorder prior to this study. In this study it the effectiveness of a multisystem aquatic therapy on behavioral, emotional, social and swimming skills of children with Autism Spectrum Disorder was tested. Multisystem aquatic therapy was divided in three phases: emotional adaptation, swimming adaptation and social integration. This study was over a ten-month program. Following this study the aqua therapy group showed definitive evidence of improvements relative to controls on functional adaptation (Vineland Adaptive Behavior Scales), emotional response, adaptation to change and on activity level (Childhood Autism Rating Scale). Swimming skills learning was also demonstrated. Multisystem aquatic therapy is useful for ameliorating functional impairments of children with Autism Spectrum Disorder, going well beyond a swimming training.
8. Bibliographic Information
DiPietro, J., Kelemen, A., Liang, Y., & Cecilia Sik-Lanyi. (2019). Computer- and robot-assisted therapies to aid social and intellectual functioning of children with autism spectrum disorder.Medicina, (8), 440. doi:10.3390/medicina55080440 Y
Children with autism spectrum disorder (ASD) experience challenges with social interactions, a core feature of the disorder. Social skills therapy has been shown to be helpful. Over the past several years, computer-assisted and robot-assisted therapies have been infiltrating the social skills teaching environment. Rapid progress in the field of technology, especially in the robotics area, offers tremendous possibilities for innovation and treatment or even education for individuals with ASD. The purpose of this study is to drive awareness of these innovative interventions in order to support the social lives of children with ASD. The goals of this study are identifying the types of Information Technology platforms that are being evaluated in computer and robot-assisted therapies for children with ASD; the various disciplines or professions studying and utilizing these computer and robot-assisted social skill therapies; the outcomes being evaluated in each trial; and if results demonstrate benefits to children with autism.
9. Bibliographic Information
Kaur, K. S., & Pathak, R. (2019). Play-based occupational therapy intervention on social skills in children with autism spectrum disorder and attention deficit hyperactivity disorder: A case series. Indian Journal of Occupational Therapy, 51(1), 31-36. doi:10.4103/ijoth.ijoth_5_19 Y
This study focuses on the social aspect of children. In children who have Autism Spectrum disorder the social aspect is one that is very difficult for children with ASD. Often children with ASD do not know how to interact with their peers and are award in social settings. This presents a great deal of issues for them going into adulthood. In addition, due to the lack of their abilities to act appropriately in social settings many limits are set for children with ASD and this can also cause further anxiety, depression and behavioral problems. This study was completed in kids 4-5 years of age with a diagnosis of ASD. Data was collected prior to starting this study to determine social skills level before and after. Play was incorporated in occupational therapy in sessions that were completed twice a week for sixty minutes. After six months the data was reviewed which showed progress was made in social skills.
Kenny, D. T. (2019). Faulty theory, failed therapy: Frances tustin, infant and child psychoanalysis, and the treatment of autism spectrum disorders. SAGE Open, doi:10.1177/2158244019832686 Y
This study focuses on infants and the treatment of autism. The infant and child psychoanalysis expounded and developmental psychology and developmental neuroscience. There are two issues in this study that are examined; How early psychoanalytic insights informed empirical developments and theoretical scholarship in both infant psychoanalysis and developmental psychology, and how the study of infant development within psychoanalysis has been derailed by faulty theorizing and failure to incorporate scientific scholarship on infant development into their theories and practice. There is review current research on infancy including psychoanalytic contributions that have incorporated scientific methods and evidence. The author also worked with Frances Tustins theory of autism as an exemplar of the problematic theorizing about infant development that remains unchallenged, even today, in some psychoanalytic circles, and how that theory is operationalized in treatment.
Bibbo, G., Kirkwood, I., Sigalas, V., &Benger, T. (2019). Radioiodine (131I) therapy in a child with autism spectrum disorder: A complex and demanding task. World Journal of Nuclear Medicine, 18(3), 293-295. doi:10.4103/wjnm.WJNM_40_18
Dae-Wook Kang, Adams, J. B., Coleman, D. M., Pollard, E. L., Maldonado, J., Sharon McDonough-Means, . . . Rosa Krajmalnik-Brown. (2019). Long-term benefit of microbiota transfer therapy on autism symptoms and gut microbiota. Scientific Reports, (1), 1. doi:10.1038/s41598-019-42183-0
Maussion, G., Rocha, C., Genevive Bernard, Beitel, L. K., &Durcan, T. M. (2019). , another in vitro model, or the missing link toward novel therapies for autism spectrum disorders? Frontiers in Pediatrics, doi:10.3389/fped.2019.00225
Ruu-Fen Tzang, Chuan-Hsin Chang, Yue-Cune Chang, & Hsien-Yuan Lane. (2019). Autism associated with anti-NMDAR encephalitis: Glutamate-related therapy. Frontiers in Psychiatry, doi:10.3389/fpsyt.2019.00440
Saaybi, S., AlArab, N., Hannoun, S., Saade, M., Tutunji, R., Zeeni, C., . . . Rose-Mary Boustany. (2019). Pre- and post-therapy assessment of clinical outcomes and white matter integrity in autism spectrum disorder: Pilot study. Frontiers in Neurology, doi:10.3389/fneur.2019.0087
Benger, M., Kinali, M., & Mazarakis, N. D. (2018). Autism spectrum disorder: Prospects for treatment using gene therapy. Molecular Autism, (1), 1. doi:10.1186/s13229-018-0222-8
Caputo, G., Ippolito, G., Mazzotta, M., Sentenza, L., Muzio, M. R., Salzano, S., &Conson, M. (2018). Effectiveness of a multisystem aquatic therapy for children with autism spectrum disorders. Journal of Autism & Developmental Disorders, 48(6), 1945-1956. doi:10.1007/s10803-017-3456-y
DiPietro, J., Kelemen, A., Liang, Y., & Cecilia Sik-Lanyi. (2019). Computer- and robot-assisted therapies to aid social and intellectual functioning of children with autism spectrum disorder.Medicina, (8), 440. doi:10.3390/medicina55080440
Kaur, K. S., & Pathak, R. (2019). Play-based occupational therapy intervention on social skills in children with autism spectrum disorder and attention deficit hyperactivity disorder: A case series. Indian Journal of Occupational Therapy, 51(1), 31-36. doi:10.4103/ijoth.ijoth_5_19
Kenny, D. T. (2019). Faulty theory, failed therapy: Frances tustin, infant and child psychoanalysis, and the treatment of autism spectrum disorders. SAGE Open, doi:10.1177/2158244019832686
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