Essay 1: Virulence factors are critical to the progress of disease, using Streptococcus pyogenes name and describe the virulence factors that allow for the stages of disease: Entry, Adhesion, Invasion, Infection (disease), Transmission. Make virulence factors the focus of this essay. You should use more than one disease caused by S. pyogenes in your answer and these diseases should be taken from different systems i.e. don’t give pharyngitis and scarlet fever the later is a consequence of the former. I recognize that portal of entry/portal of exit does not have virulence factors involved but your essay should at the least name the portal of entry/exit and mode of transmission because these are frequently different. How should this disease be treated, how can it be prevented? You have time to write your essay and use it. Be comprehensive explain how some pathogenicity factors are important in all/some diseases caused by S. pyogenes and how some are unique to a single disease expression of this pathogen, e.g. strains that cause pharyngitis tend to have different virulence factors than those which cause necrotizing fasciitis. Recognize that THIS IS AN ESSAY ABOUT VIRULENCE FACTORS, make that your focus not signs and symptoms of disease. To help you out the diseases caused by S. pyogenes include: integumentary – necrotizing fasciitis, impetigo, erysipelas, respiratory pharyngitis (scarlet fever, rheumatic fever), pneumonia, Circulatory- bacteremia, sepsis, septic shock, pericarditis https://www.cdc.gov/groupastrep/diseases-hcp/index.html
Essay 2: Exotoxins are critical to the signs and symptoms suffered in many diseases of both the digestive and nervous system. You will compare and contrast the role of exotoxins (often termed neurotoxins) in at least one nervous system disease which is tetanus OR botulism and one digestive system disease (may not be either Clostridium botulinum nor Clostridium difficile) to fully explore their role in disease. Realize that exotoxins in GI diseases are often termed enterotoxins). Most important is how the action of the toxin on the body/cells leads to the specific symptoms of that disease? How does the toxin gain entry into the target cells? What does it do to them? Are there similarities between how the toxins work or differences? In general how are these diseases acquired? How are they treated? THIS IS AN ESSAY ABOUT EXOTOXINS not the symptoms of disease make that your focus. Be specific, be detailed, include citations and references.
ALL QUESTIONS MUST BE ANSWERED
Two additional high quality resources (use the links below) in addition to the textbook for each essay
Online textbook: https://openstax.org/books/microbiology/pages/1-introduction Peer reviewed journal articles https://scholar.google.com www.cdc.gov www.nih.gov www.fda.gov www.who.gov
Citation and references in APA format and appropriately cited
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